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Virulence is the measurement of the ability to cause diseases in the host. Side by Side Comparison – Virulence vs Pathogenicity in Tabular Form Similarities Between Virulence and Pathogenicityĥ. Virulence and pathogenicity are two terms related to the ability to cause diseases and the degree to cause diseases. The second possibility is the pathogen entering the host and causing disease, while the third outcome may be an equilibrium where pathogen and host will live together and minimize the harm caused by the pathogen. The first possibility is that the pathogen may be removed from the primary defense system of the host. Moreover, after an infection, there may be three possible outcomes. However, in the absence of even one of these factors, the disease will not occur. Three factors are important in disease contraction: pathogen, host, and environmental factors. Host and pathogen should come in contact in order for a disease to contract. 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